another personal thing that i follow is, never settle for pdr on a 1st and 2ndary weapon when you have a tertiary weapon available. (unless i mean you get that extra pdr line on your 3rd line.)
So realistic potential with the best effectiveness in my perspective is this: 50% boss with 9% atk bonus on weapon; 60% boss/21% atk with 9% atk bonus on 2ndary; 21% atk 30% pdr and 9% atk on bonus on the heart.
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