It's coming! A release date has finally been announced: November 4th! and you can pre-purchase the game now on Steam. If you pre-purchase the game with The Binding of Isaac already in your Steam library you get 33% off.
The game itself is a complete reworking of the original The Binding of Isaac, including its expansion, The Wrath of the Lamb, as well as brand new content which is more new content than the original and Wrath of the Lamb combined. tons of new items, new features, new rooms, bigger dungeons, new characters and so on!
Notably there is also a local co-op mode and the ability to save the game at any time during your run.
I can't post the trailer because it has nudity in it, but here is some gameplay:
Gameplay starts at 6:08