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Math map: Use a scientific calculator. I usually keep the Windows calculator open next to the game window (make sure it's in Scientific mode, or else the answers will be wrong).
Nurses and the 2 minute map are unavoidable in terms of speeding things up, you can't make those clear any faster. To make the two minute wait room easier, though, you are not required to kill the ninjas in there, just sit at the top and wait for time to run out.
An additional tip: In the art room (with the NPC you "ask out"), just hold Enter and you'll eventually get the right option chosen, because it seems to be random whenever the window comes up.
I have no idea if you already do all of this, since you never mentioned how you do things.
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